The smart Trick of ceesdekker That Nobody is Discussing
The smart Trick of ceesdekker That Nobody is Discussing
Blog Article
‘Sure, that is definitely about correct. I seek for a physical knowledge of Organic systems within a base-up way. I do think you can distinguish 3 lines of analysis in my team for the time being. The primary fears chromosome structure: How would you receive a metre-long DNA polymer folded and organised in such a microscopic cell? We have now made visualisation methods that let us to review how, for example, SMC proteins loop DNA (video on Youtube) in an effort to Establish up chromosomes.
Our team reports bacterial cell division and is aiming to represent a ‘base up biology’ in synthetic cells that may autonomously divide. Our main desire lies in cell division, chromatin structure, and spatial Command.
‘It was simply a make any difference of finding up a ebook on cell biology and beginning to read through. I had originate from a world of extremely-large vacuums, cryostats and quantum phenomena, and now I had been Functioning at area temperature with molecular biology kits.
Sculpting nano-electrodes by using a transmission electron beam for electrical and geometrical characterization of nanoparticles.
2010, developed a brand new way (‘wedging transfer’) to control nanostructures; 1st report of DNA translocation as a result of graphene nanopores; and understood hybrid nanopores by directed insertion of α-hemolysin into solid-state nanopores
SMC complexes can go Bodily roadblocks bigger than their ring dimension, indicating a nontopological mechanism for DNA loop extrusion
We shape bacteria into sorts that deviate from their purely natural phenotype. Precisely, I'll present our capability to shape Are living E. coli micro organism into novel designs for example rectangles, squares, triangles and circles.
2000, discovery that nanotubes can have remarkable substantial current densities; settled the controversial cees dekker difficulty of electronic transport by DNA molecules by measurements of insulating behavior at the single molecule stage; and demonstration of the AFM technique for solitary-molecule manipulation of nanotubes
This "Cited by" count involves citations to the subsequent article content in Scholar. The ones marked * might be distinct with the short article in the profile.
Right now, we also recognized that it should be feasible to make use of just one semiconducting carbon nanotube to create a transistor — and we set out to really make it. We stretched unique semiconducting nanotubes throughout metallic electrodes and applied the underlying silicon substrate like a gate electrode, setting up the basic a few-terminal structure of the area-impact transistor (Fig.
Example (four) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is proven in grey, the rim of your pore is highlighted in purple, plus a 3D rendering with the motion from the DNA rod is exhibited.
Later on we spoke again briefly since Dekker felt that our dialogue of his religion immediately grew to become purely philosophical, Whilst it also concretely assists him in his operate.
Developments in nanotechnology during the nineteen nineties built building electronic devices from single molecules a possibility. Cees Dekker recounts how his team created a room-temperature transistor according to just one carbon nanotube.
Supercoiling-dependent DNA binding: quantitative modeling and programs to bulk and one-molecule experiments